As a boxer, Ali will be remembered as a three-time world heavyweight champion who won 56 bouts over a 21-year career.
Muhammad Ali, 1942-2016Muhammad Ali was born Cassius Macellus Clay Jr on January 17, 1942, in Louisville Kentucky
Aged 22, he took on heavyweight champion Sonny Liston in Miami. He won and proclaimed to the world: "I am the world's greatest!"
Ali was the first man to win heavyweight titles three times
Ali attended his first Nation of Islam meeting in 1959 and converted to Sunni Islam in 1975
In 1967, he famously refused to fight in Vietnam, citing religious reasons
Married four times, he had seven daughters and two sons
He was diagnosed with Parkinson's disease in 1984, at the age of 43
Ali died late on June 3, 2016, in a hospital in Arizona after being admitted with respiratory problems
Ali's funeral will take place in Louisville
Ali is survived by his wife, the former Lonnie Williams, who knew him when she was a child, along with his nine children
Elvis Presley was the 20th century's king of Rock 'n' Roll, and Ali was the Elvis of Boxing, he once said.
Most of the time, Ali dispensed with comparisons or complex superlatives. He was, simply, "the Greatest".
If anybody took this self-congratulation for arrogance, Ali had an answer ready. "It's hard to be humble when you're as great as I am," he said.
He died on Friday aged 74, after a decades-long struggle with Parkinson's disease - a slowly worsening brain disorder that never wholly subdued one of the sporting world's biggest personalities.
As a boxer, he will be remembered as a three-time world heavyweight champion who won 56 bouts over a 21-year career.
He was born in the American South of 1942 and the segregation era, taking his original name, Cassius Clay, from his father, a sign and mural painter. His mother, Odessa Clay, was a housemaid.
In 1954, it was Ali's quick tongue that got him into boxing.
The skinny 12-year-old sought out local police officer Joe Martin to report his red bicycle as stolen in his home town of Louisville, Kentucky.
Ali said he would whip the thief who had pinched his Christmas gift. Martin - who also ran a boxing gym - said Ali had better learn how to fight to come good on his threat.
Six years later, he won a gold medal in the 175-pound division at the 1960 Olympic Games in Rome and launched his professional career.
Nation of Islam phaseA title fight against Sonny Liston won him fame in 1964. Ali was an underdog who became world heavyweight champion by pounding his rival to defeat in six rounds - a big upset in sports history.
Two days later, he shocked the US again by embracing the Nation of Islam - a religious group that seeks to improve life for blacks in the US, but has been criticised for black supremacist ideas.
He also dropped what he called his "slave name" and became Muhammad Ali.
Ali's links with activist Malcolm X and his spiritual mentor, Elijah Muhammad, worried conservatives, but he was an inspiration for many.
"As a child, the first action figure my parents got me was of Muhammad Ali. For my generation, he was perhaps the largest and most influential pop culture icons for African-Americans and Muslims," Dawud Walid, from the Council on American-Islamic Relations, an advocacy group, told Al Jazeera.
Ali risked his career - and his reputation - to oppose the Vietnam War. Citing religious beliefs, he refused to serve in the US srmy and was subsequently arrested for committing a felony. "I ain't got no quarrel with them Vietcong," he said.
The conflict was broadly popular in the US at that time, and Ali was stripped of his titles, had his boxing license suspended and was found guilty of an offence at a 1967 trial. The US Supreme Court reversed the conviction four years later.
"He was ahead of the curve in calling the Vietnam War wrong and he doesn't get enough credit for that," Michael McPherson, director of the anti-war group, Veterans for Peace, told Al Jazeera.
"He was an African-American Muslim who criticised US foreign policy. It's hard to do that today; but back then, black people had to prove their allegiance, patriotism and belief in America. I wish we had more people who speak out when something is wrong."
Back in the ring in 1970, Ali continued to "float like a butterfly, sting like a bee" against the likes of George Foreman and Joe Frazier.
He lost the Fight of the Century to Frazier at Madison Square Garden after 15 rounds in 1971, but beat him back four years later in the capital of the Philippines - the so-called Thrilla in Manila.
Rope-a-dope trickFans have questioned Ali's style: he held his hands low and backed away from punches, rather than dodging and weaving.
His "rope-a-dope" trick of leaning back on the ropes to avoid blows helped him win a knockout victory against Foreman in a 1974 title fight - the Rumble in the Jungle - in Kinshasa, Zaire, now called the Democratic Republic of Congo.
As well as being able to take a punch, Ali fought with speed, courage and good footwork. He ranks among the greatest boxers of all time, alongside Sugar Ray Robinson, Joe Louis, Henry Armstrong and others.
He fought his final professional fight and married his fourth wife, Lonnie Williams, in the 1980s. Having left the hard-line Nation of Islam, Ali embraced the mainstream Sunni faith and remained politically active despite the onset of Parkinson's.
He met Iraqi leader Saddam Hussein in 1990 and brokered the release of Americans who had been held hostage after the invasion of Kuwait. In 2011, he called on Iran to release the captive US hikers Shane Bauer and Josh Fattal.Ralph Ali, Frazier & Foreman we were 1 guy. A part of me slipped away, "The greatest piece" https://t.co/xVKOc9qtub— George Foreman (@GeorgeForeman) June 4, 2016
One of Ali's most celebrated moments came in 1996, when he lit the cauldron at the opening ceremony to the Atlanta Olympics. His willingness to appear despite a visibly twitching arm touched many in the crowd.
It was a "moment of infinite sadness, yet supreme majesty", wrote Ken Rosenthal in The Baltimore Sun. Parkinson's Disease was "proving a more difficult opponent than Joe Frazier" for the champion.
The father-of-nine's less-frequent television appearances showed how even the cleverest and strongest men are worn down by a brain illness.
"Parkinson's sufferers say they can still think the things they thought before they had the disease - it just takes them a lot longer," Peter Schmidt, who heads research programmes at the National Parkinson Foundation, told Al Jazeera.
"You can imagine how hard it was for Ali, who joked around so much and for whom timing was so important. That's why he remained such an inspiration - even though he was so seriously affected, he was always joking and continued to have such an infectious personality."
While the sporting world has had many champions, few can match Ali for charisma and swagger.
In his own words: "I won't miss fighting, fighting will miss me."
Follow James Reinl on Twitter: @jamesreinl
Source: Al Jazeera