Monday, 30 December 2013

Scientists Have Discovered A Drug That Blocks AIDS


AIDS1-BLock
Scientist at the Gladstone Institutes have identified the precise chain of molecular events in the human body that drives the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS.
“Gladstone has showed how the body’s own immune response to HIV causes CD4 T cell death via a pathway triggering inflammation, and secondly by identifying the host DNA sensor that detects the viral DNA and triggers this death response,” said Dr. Robert F.
Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells — and now are planning a Phase 2 clinical trial to determine if this drug or a similar drug can prevent HIV-infected people from developing AIDS.
Two separate journal articles, published simultaneously in Nature and Science, detail the research from the laboratory of Dr. Warner C. Greene, who directs virology and immunology research at Gladstone, an independent biomedical-research nonprofit.
His lab’s Science paper reveals how, during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells. This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death.
As revealed in Nature, this repetitive cycle of abortive infection, cell death, inflammation and recruitment of additional CD4 T cells to the infection “hot zone” ultimately destroys the immune system and causes AIDS.
Siliciano, a professor of medicine at Johns Hopkins University, and a Howard Hughes Medical Institute investigator. “This one-two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene’s lab has been able to identify a potential new therapy for blocking the disease’s progression and improving on current antiretroviral medications.”
InformationNigeria

The Most Healthy State in America Is ..


the, most, healthy, state, in, america, is, ...,
The Most Healthy State in America Is ...
Image Credit: motherliving
We know which American states are the hardest working — but which states have the most sloths and couch potatoes?
According to the Centers for Disease Control and Prevention (CDC), Americans in the South and in the Midwest get the least amount of exercise in the country.
On the flip side, Colorado is the most active state in America, far surpassing most other states with the amount of exercise its residents regularly do.  
The study, published earlier this year, asked nearly half a million respondents how much time they regularly spent on aerobic and muscle-strengthening activities outside of work. Then it calculated how many respondents met the CDC exercise guidelines (75-150 minutes of aerobics and at least two sessions of muscle-strengthening exercises per week).
Without further ado, here are the 10 least active U.S. states (according to what percent of the population met the CDC guidelines):
1. Tennessee (12.7%) — tied
1. West Virginia (12.7%) — tied
3. Mississippi (14.2%)
4. Alabama (15.0%)
5. Louisiana (15.5%)
6. South Dakota (16.0%)
7. Oklahoma (16.2%)
8. Kansas (16.5%)
9. Arkansas (16.7%)
10. Iowa (17.2%)
And here is a map illustrating the breakdown by state:
Source: Centers for Disease Control and Prevention
Another survey by the CDC last year found similar results (seven of the states from the list above can also be found below). The survey asked, "During the past month, did you participate in any physical activities?"
Here are the 10 states with the lowest number of people who exercised:
1. Arkansas (68.5%)
2. West Virginia (69.0%)
3. Mississippi (69.2%)
4. Louisiana (70.1%)
5. Kentucky (70.3%)
6. Tennessee (71.4%)
7. Oklahoma (71.7%)
8. Alabama (72.8%) — tied
8. Texas (72.8%) — tied
10. Indiana (74.1%)
The data from these two surveys is in line with the CDC's assessment that "Americans living in the South are more likely to be less physically active than Americans living in the West, Northeast and Midwest regions of the country."
However, it's important to keep in mind that physical exercise is also closely tied to socioeconomic factors: those with financial security and leisure time are more likely to be able to eat healthy and pursue fitness.
As the CDC noted, non-Hispanic white adults, adults with more education, and adults whose income is above the poverty level are more likely to be physically active. Many of the Southern and Midwestern states listed here have historically poor black populations and low figures for high school graduationcollege graduation, and income.
But the correlations between exercise and health are real. A Gallup-Wellbeing Index from the same time period "found West Virginia had the fattest residents in the country with more than 33% of its population obese, while Colorado had the lowest obesity rate in the country at 18.7% of residents." It's no surprise then that Colorado had the highest number of people who met the CDC exercise guidelines (27.3%).
While it may seem like common sense, these figures indicate that regular exercise does lead to healthier living.
But what can we do to make sure that we all live healthier lives? While "half the adults in the United States are meeting the aerobic guidelines and a third are meeting the muscle-strengthening recommendations," only 20% are meeting both, according to the CDC. "This is a great foundation to build upon, but there is still much work to do," a CDC spokesperson added in a statement.
If you want to check if you are getting enough exercise, or if you want to learn how to incorporate more exercise in your daily routine, check out the CDC's website on Physical Activity. Here's to a healthier and happier new year for all of us.

11 Famous Billionaires Who Never Graduated From College

Eileen Shim's avatar image By Eileen Shim  


With rising tuition costs and mounting student debt, college is becoming a tougher choice for many young people. The competition for admission is getting more fierce every year, and there is no guarantee that a college diploma will translate to a well-paying job after graduation.
Yet, some people have earned success without securing a college degree. Through a combination of entrepreneurship, ambition, and luck, these 11 highly-successful businessmen have built empires from scratch. 

1. Bill Gates

Net worth: $72 billion
College: Dropped out of Harvard University
Nicknamed "Harvard's most successful dropout," Bill Gates is officially the richest man in the world. The Microsoft founder decided after two years of college that his time was better spent starting his own company, which he founded with his friend Paul Allen, another dropout billionaire. Microsoft eventually became the biggest tech company in the world (a title that Apple stole in 2010). Through his nonprofit Bill & Melinda Gates Foundation, he has also donated billions to charitable causes. What else is there to say?

2. Amancio Ortega

Via: Celebrity Net Worth
Net worth: $57 billion
College: Did not attend
Kate Middleton is among the millions of people who shop at Zara every year. But few customers know that its owner, Amancio Ortega, is the third richest man in the world. The son of a railway worker and a housemaid, Ortega decided at an early age to get a job rather than matriculate in school. After working for a local shirt maker, he started his own manufacturing company and organized thousands of local Galician women into sewing cooperatives. Since then, the "fast fashion" brand has taken over the world.

3. Michele Ferrero

Via: Celebrity Net Worth
Net worth: $20.4 billion
College: Did not attend
Who knew there was so much money in Italian chocolate? Michele Ferrero, along with his family, built a bakery business after World War II. He created his signature chocolate treat in his laboratory, which helped the family business become a chocolate empire. Now he's known as a real-life Willy Wonka, and with Ferrero Rochers, Tic Tacs, Kinder Eggs, and Nutella in his portfolio, he certainly deserves the title.

4. Mark Zuckerberg

Net worth: $19 billion
College: Dropped out of Harvard University
While the film The Social Network did not present him favorably, Mark Zuckerberg still deserves credit for founding the biggest social media website in the world. The Facebook CEO showed prodigious talent with computers, and had created many programs even before he enrolled at Harvard. Facebook remains his signature achievement, and the controversy surrounding the company's early stages has been immortalized on film.

5. Michael Dell

Net worth$15.9 billion
College: Dropped out of University of Texas
As a teenager, Michael Dell often took apart and rebuilt computers. In high school, he developed a targeted marketing system to sell newspaper subscriptions, which made him $18,000 in one year. By the time he was in college, he combined his interests in tech and business to start his own company, which allowed him to build and sell computers directly to customers. It was so successful that he left college to focus on it full time, and Dell is now one of the biggest PC makers in the world.

6. Francois Pinault

Net worth: $15 billion
College: Did not attend
If success is the best revenge, then Francois Pinault certainly is getting the last laugh. He dropped out of high school to work at his father's lumber mill. Now, he is the CEO and majority shareholder of the fashion conglomerate Kering, and owns powerful brands like Gucci, Alexander McQueen, Yves Saint Laurent, as well as Christie's auction house.

7. Ralph Lauren

Net worth: $7.7 billion
College: Dropped out of Baruch College
The son of Jewish immigrants from Poland, Ralph Lauren developed an early penchant for fashion while selling ties to his schoolmates. After briefly serving in the U.S. Army, he worked for Brooks Brothers and eventually started his own company at 26, selling his necktie designs. Now his Polo Ralph Lauren brand, and the iconic polo shirt, are known around the world.

8. Richard Branson

Net worth: $4.6 billion
College: Did not attend
This real-life Tony Stark dropped out of school at 16, and went on to found the Virgin Group, which includes Virgin Mobile phones, Virgin Atlantic Airlines, and now, the Virgin Galacticspace tourism agency. While Richard Branson has enjoyed his "billionaire playboy" image, he has also pursued many charity causes through his nonprofit foundation. It seems like for Branson, not even the sky is the limit.

9. Ingvar Kamprad

Net worth: $3.3 billion
College: Did not attend
Ingvar Kamprad demonstrated his entrepreneurial spirit from an early age. He would buy matches in bulk from Stockholm and sell them individually to make a profit. When he was 17, he decided to start a company with cash his father gave him. Now, IKEA is the largest furniture retailer in the world. You can thank Kamprad for furnishing the dorm rooms and apartments of everyone you know.

10. Oprah Winfrey

Net worth: $2.9 billion
College: Dropped out of Tennessee State University (but eventually earned a diploma in 1987).
Oprah Winfrey is not just a person — she is an institution. Despite her difficult childhood, she found her talent as an engaging media personality. She left college to co-anchor an evening news program in Baltimore, just one credit shy of graduation. Now she has her own TV channel, radio program, magazine, book club, and most importantly, her image brand.

11. Steve Jobs

Net worth at the time of death: $7 billion
College: Dropped out of Reed College
It would be remiss to talk about Gates without bringing up his main competitor, Steve Jobs. Though the Apple founder died in 2011, his impact on technology remains strong today. Just one semester at Reed convinced him that the tuition was too much of a financial burden on his parents, and he dropped out. After working at Atari, he went on to found Apple with his partner Steve Wozniak. Apple is now one of the biggest tech companies in history
.PolicyMic

7 Photos Of a Man You Wouldn't Believe is a World President

Matt Essert's avatar image By Matt Essert  

7, photos, of, a, man, you, wouldn't, believe, is, a, world, president,
7 Photos Of a Man You Wouldn't Believe is a World President
Image Credit: Taringa
José Mujica is the president of Uruguay, but you wouldn't know it from looking at him. Sometimes called the world's poorest president, Mujica, who took office March 1, 2010, has donated about 90% of his $12,000 monthly salary to charities benefiting the poor and entrepreneurs.
Unlike other heads-of-state who don discreet butlersfleets of yachts, and wine cellars with vintage Champagnes, Mujica lives a simple life in the home he's occupied for years. 
Take a look for yourself.

1. President José Mujica

Mujica sits between his Vice President Danilo Astori and newly-appointed Finance Minister Mario Bergara. An atheist, Mujica has led Uruguay to legalize marijuana and same-sex marriage while enacting one of the region's most sweeping abortion rights laws. 

2. A certified guerilla badass

Via: Imgur
As a guerrilla fighter for Tupamaros (a "Robin hood" organization that stole from the rich and gave to the poor) he was imprisoned twice, escaped once, and was only apprehended after being shot six times by the police. He was released 14 years later when a constitutional democracy was restored in Uruguay. 

3. A presidential "palace"

Via: Imgur
This is Mujica's home. Instead of living in the Uruguayan presidential palace, he chose to stay in the place where he and his wife have lived for years. On their property, they grow chrysanthemums that they sell in local markets.

4. His motorcade


Mujica chooses to drive himself around in his 1987 Volkswagen Beetle which, until he added half of his wife's assets (land, tractors, and a house), accounted for the entire value of his declared wealth: $1,800. 

5. José and Luciá

Mujica shortly after his election win in 2009 with his wife Luciá Topolansky, who is now also a Uruguayan senator. 

6. A real sweet dude

And here he is with Steven Tyler and Joe Perry of Aerosmith because ... well why not?

7. Keep it real, José


PolicyMic

Obama, Hillary Clinton Polled As Most Admired Living Man And Woman 2013



Obama topped the annual list for the sixth consecutive year, a typical ranking for a sitting U.S. president, the polling organization said.

But the percentage of those surveyed who choose him as the most admired man fell to 16 percent this year, down from 30 percent in 2012.

The president's job approval rating has dropped during a year marked by a botched healthcare rollout and stalled legislative initiatives at the start of his second term.

Clinton earned the top spot among most admired women for the 12th consecutive year and 18th time overall, more than any other woman in the poll's history.

Fifteen percent of Americans surveyed gave the former first lady and U.S. senator the highest ranking, down from 21 percent who named her as the most admired woman last year, the poll showed.

Gallup said its data came from a poll of 1,031 adults between Dec. 5 and 8, and had a margin of error of plus or minus 4 percentage points.

Other men named to the list included former U.S. presidents George W. Bush, Bill Clinton and Jimmy Carter; Pope Francis and the Reverend Billy Graham; actor and director Clint Eastwood; Microsoft Corp co-founder and philanthropist Bill Gates; U.S. Senator Ted Cruz of Texas and former Republican presidential candidates Mitt Romney and Ron Paul.

The women who finished behind Hillary Clinton included talk show host Oprah Winfrey, first lady Michelle Obama, former Alaska Governor Sarah Palin, former Secretary of State Condoleezza Rice and actress Angelina Jolie.

Also on the list were Malala Yousafzai, the Pakistani teenager shot in the head by the Taliban for demanding education for girls; German Chancellor Angela Merkel, and Britain's Queen Elizabeth and Duchess of Cambridge, Kate Middleton.

(Reporting by Colleen Jenkins; Editing by Ian Simpson and Vicki Allen)
HuffingtonPost

Former Mayor Injured, Husband Killed By Family Dog

 By 


Diane Vick, former mayor of Bullhead City, Arizona, was injured and her husband killed when their family dog attacked them on Saturday.
According to ABC 15, Tom Vick, a social studies teacher, died Sunday morning after being attacked by the family's boxer. The Las Vegas Review-Journal reports Diane Vick called 911 at 5:45 p.m. on Saturday, saying her husband had been badly bitten.
The attack came after the couple tried to break up a fight between the boxer and another family pet, which ABC 15 reports is a cocker spaniel.
Jack Hakim, current mayor of Bullhead City, told the Arizona Republic the attack was "pretty devastating" and that Diane Vick "was pretty well beat up."
“We’ve had dog bites before but never something like this,” Hakim said. “It’s very sad for us in Bullhead City."
"We’re just grateful that at least one of them was able to survive," Hakim continued.
HuffingtonPost

Cash-Gate: Malawi’s Joyce Banda Fights Deep-trenched Corruption


JOYCE-BANDA

BBC: Malawi’s Joyce Banda sacks cabinet amid corruption row

Malawi’s President Joyce Banda has sacked her cabinet amid allegations of widespread corruption in government.
Several officials have been caught allegedly with money hidden under their beds and in their cars, reports the BBC’s Raphael Tenthani from Malawi.
Last month, top finance ministry official Paul Mphwiyo, who was seen as an anti-corruption crusader, was shot and wounded, our reporter says.
By , Lilongwe; Telegraph
Joyce Banda, the embattled president of Malawi who is facing a multi-million pound corruption scandal that has swallowed up to a third of the budget of her impoverished country, has said she will not be a “cry baby” over the decision by Western donors including Britain to freeze aid.
Mrs Banda, southern Africa’s first female head of state, became the West’s darling for her reformist agenda after the death of her autocratic predecessor, said she should be given credit for tackling the graft head-on.
In an exclusive interview with The Daily Telegraph this week, she said she understood the need for British politicians and taxpayers to have confidence in her government – and pledged to work hard to ensure trust is rebuilt.
“If you want me to be a cry baby I cannot, I am the leader of a country. If you want to give me something and then withdraw it, fine, I must respect your decision. I am not going to cry over it, no,” she said.
“I have made an announcement that if you are my daughter, my son, my party official, my cabinet minister, and you find yourself involved in this, you are going to go to jail. I am not going to stand in the way.
“Yes, people in the UK will feel they are justified to withhold aid but I also think the UK will look at a new breed of leaders across the continent that have decided to fight it.”
The so-called Cashgate scandal first came to light following the near-fatal shooting of the Malawian budget director, who is thought to have been about to blow the whistle on the scam.
In the police raids that followed, civil servants were discovered with thousands of dollars stashed in their car boots and at their homes.
So far, 68 people including the ministers of finance and justice and a score of senior officials have been arrested for allegedly siphoning off money from government coffers through fraudulent use of procurement systems.
Foreign donors including Britain, the EU and Norway, who have pumped millions of pounds into reviving Malawi’s stricken economy, providing 40 per cent of its budget, have suspended all direct aid and made no secret of their fury over the systematic looting.
Mrs Banda insists the corruption began 15 years ago and was ignored by previous presidents but that she has been working behind the scenes for months to put a stop to it.
“There’s no one who can come and say they are more traumatised that we are about this,” she said.
“We have worked extremely hard to turn our country around – I have not slept for more than six hours for a year and a half. And we thought we had come out of the woods but then we find we are going backwards. There’s no way we can be looked upon as those that don’t care.”
She claims to have had to step up her security amid death threats, and said one ambassador told her she presided over a “country of thieves”.
Mrs Banda said that her neighbours in the region had told her she was a “fool” to raise her hand about the leakage, especially since she is coming up for her first elections since taking office, in May next year.
“It is a high cost for me just doing that, as a politician, six months before elections because for everyone I have arrested, I have lost a whole village of votes,” she said.
“I did not realise this – I thought they would look at the issues but no, they say ‘but it’s our daughter that you have arrested’.”
Many Malawians believe that Mrs Banda, 63, a former gender activist and factory owner who sold off the presidential jet and slashed her salary after coming to power, was either involved or at least knew about the corruption.
But most of the key donors say they are yet to see any evidence of her complicity and, for the moment, are giving her the benefit of the doubt.
She said she had been “bruised and smeared” by the allegations of involvement, but would not be deterred.
“I am prepared to get bruised because I just feel that this must stop and must stop now. We are finishing 50 years of independence this year, we are going into the next 50 years,” she said.
“It is my wish that this rot remains in this millennium. That we go into the next one rejuvenated, clean and ready to prosper.”
Her ambition – shared by donors, although they say the timeframe is optimistic – is to stop the leaks from the budget, exploit natural resources including possible oil reserves discovered in Lake Malawi and be free of foreign aid within a decade.
“The donors have not walked away for the first time. They come and go and come and go but we are here, we did not die,” she said.
“Sometimes when these things happen, you grow up, you find other ways. We must become creative, we are not going to be dependant forever. Perhaps this is a golden opportunity for us.
“If we do certain things right and if we are as determined as we are as I sit here, in 10 years’ time the donors shall be our partners, not our providers, and we shall have weaned ourselves from budget support.”
 NewsRescue